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Localisation of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs

Steven R

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This dedicated mitochondrial pool of ubiquinol acts as a potent, radical-trapping antioxidant, directly neutralizing lipid peroxyl radicals within the inner mitochondrial membrane and thereby shielding the organelle from lipid peroxidation and subsequent ferroptotic collapse (38)

NLCs improve upon SLN technology by incorporating liquid lipids that create imperfect crystal structures, enabling higher drug loading capacity and reduced compound expulsion during storage